"Militants attacked police checkpoints in Sangin district on Saturday night. Security forces responded to the attack. The clash left five policemen and several militants killed," Xinhua reported, citing a security official.
Eight police personnel were also injured during the attack.
The injured were shifted to a hospital in Lashkar Gah, Helmand province's capital. A senior police official was among those killed, the official added.
Details of casualties on the militants' side remain unclear.